Assessment of Potential Drug Interactions in Asthma Patients at a Tertiary Care Hospital in Tamilnadu
Objective: The aim of the study was to assess the potential drug interactions in asthma patients at a tertiary care hospital
Methods: The Prospective observational study was carried out over a period of 10 months from July-2018-April 2019, in the respiratory department of a tertiary care hospital. The Institutional ethics committee approval was obtained for the study.229 patients aged between 17-70years were randomly selected from among patients diagnosed with asthma The patient data was collected from the case sheets of the hospitalized patients and all the necessary relevant data was collected from the case notes such as treatment charts, and laboratory data reports were entered in the predesigned proforma.According to our study drug interactions were classified on their severity basis and risk of potential drug –drug interactions was estimated by using computerized drug-drug data based system such as drugs.com, medscape, upto date and Micromedex ® software (2.7) Results: A total of 229 Patient prescriptions were analyzed. These prescriptions contained a total of 916 drugs. A total of 516 Drug drug interactions (DDIS) were identified. Most of the DDIs were pharmacokinetic drug interactions (47%) followed by pharmacodynamic mechanisms (22%). The study findings showed that the prescriptions for respiratory disease conditions had the greatest number of drug interactions on an average. Severity assessment showed that majority of the DDIs were moderate (75.38%) Major (4.45%) followed by Minor (20.15%). The study results showed that as the number of drugs increases in a prescription, the number of DDIs also increases.