IT’S COCOA EXTRACT BENEFIT TO MALE DYSLIPIDEMIA ATHEROGENIC CENTRAL OBESITY?
Background and objective: Obesity a new epidemic throughout the world and impact to economic and health. This study aimed to examine the effect of cocoa supplement on atherogenic dyslipidemia in central obesity male, based on lipid profile, levels of TNF- α, oxidized-LDL and apolipoprotein B.
Methods and design: Double Blind Clinical Trial by recruiting 34 male subjects, at Hasanuddin University hospital Clinic, aged between >25-55 years, waist circumference of >90 were treated for 8 weeks. Intervention Group (n=17) received 4 gram of cocoa extract cap/day, and control group (n=17 ) received placebo. Both groups had a 15% energy restriction and fat < 25% without any change in activities.
Result: The study showed after 8 weeks, there was no changes on total cholesterol and triglycerides levels in both groups (p>0.05), LDL-C decreased significantly in both groups. There were no changes on TNF- α, ox-LDL and apo-B levels in both groups (p>0,05). HDL-C increased significantly in cocoa group (p=0.04) in atherogenic cocoa group (p=0.04)
Conclusion: cocoa extract supplementation within a hypocaloric and low fat diet increased HDL-C, decreased triglyceride in atherogenic dyslipidemia. No significant changes showed in TNF- α, ox-LDL and apo- B levels in both groups